Paper · arXiv 2509.06467
Does DINOv3 Set a New Medical Vision Standard?
Che Liu, Yinda Chen, Haoyuan Shi, Jinpeng Lu, Bailiang Jian, Jiazhen Pan, Linghan Cai, Jiayi Wang, Yundi Zhang, Jun Li, Cosmin I. Bercea, Cheng Ouyang, Chen Chen, Zhiwei Xiong, Benedikt Wiestler, Christian Wachinger, Daniel Rueckert, Wenjia Bai, Rossella Arcucci
DINOv3, a self-supervised vision transformer, demonstrates strong performance across various medical vision tasks without domain-specific pre-training, though it shows limitations in deeply specialized domains and does not consistently follow scaling laws in the medical domain.
Abstract
The advent of large-scale vision foundation models, pre-trained on diverse natural images, has marked a paradigm shift in computer vision. However, how the frontier vision foundation models' efficacies transfer to specialized domains remains such as medical imaging remains an open question. This report investigates whether DINOv3, a state-of-the-art self-supervised vision transformer (ViT) that features strong capability in dense prediction tasks, can directly serve as a powerful, unified encoder for medical vision tasks without domain-specific pre-training. To answer this, we benchmark DINOv3 across common medical vision tasks, including 2D/3D classification and segmentation on a wide range of medical imaging modalities. We systematically analyze its scalability by varying model sizes and input image resolutions. Our findings reveal that DINOv3 shows impressive performance and establishes a formidable new baseline. Remarkably, it can even outperform medical-specific foundation models like BiomedCLIP and CT-Net on several tasks, despite being trained solely on natural images. However, we identify clear limitations: The model's features degrade in scenarios requiring deep domain specialization, such as in Whole-Slide Pathological Images (WSIs), Electron Microscopy (EM), and Positron Emission Tomography (PET). Furthermore, we observe that DINOv3 does not consistently obey scaling law in the medical domain; performance does not reliably increase with larger models or finer feature resolutions, showing diverse scaling behaviors across tasks. Ultimately, our work establishes DINOv3 as a strong baseline, whose powerful visual features can serve as a robust prior for multiple complex medical tasks. This opens promising future directions, such as leveraging its features to enforce multiview consistency in 3D reconstruction.