Paper · arXiv 2505.16938
NovelSeek: When Agent Becomes the Scientist -- Building Closed-Loop System from Hypothesis to Verification
NovelSeek Team, Bo Zhang, Shiyang Feng, Xiangchao Yan, Jiakang Yuan, Zhiyin Yu, Xiaohan He, Songtao Huang, Shaowei Hou, Zheng Nie, Zhilong Wang, Jinyao Liu, Runmin Ma, Tianshuo Peng, Peng Ye, Dongzhan Zhou, Shufei Zhang, Xiaosong Wang, Yilan Zhang, Meng Li, Zhongying Tu, Xiangyu Yue, Wangli Ouyang, Bowen Zhou, Lei Bai
Abstract
Artificial Intelligence (AI) is accelerating the transformation of scientific research paradigms, not only enhancing research efficiency but also driving innovation. We introduce NovelSeek, a unified closed-loop multi-agent framework to conduct Autonomous Scientific Research (ASR) across various scientific research fields, enabling researchers to tackle complicated problems in these fields with unprecedented speed and precision. NovelSeek highlights three key advantages: 1) Scalability: NovelSeek has demonstrated its versatility across 12 scientific research tasks, capable of generating innovative ideas to enhance the performance of baseline code. 2) Interactivity: NovelSeek provides an interface for human expert feedback and multi-agent interaction in automated end-to-end processes, allowing for the seamless integration of domain expert knowledge. 3) Efficiency: NovelSeek has achieved promising performance gains in several scientific fields with significantly less time cost compared to human efforts. For instance, in reaction yield prediction, it increased from 27.6% to 35.4% in just 12 hours; in enhancer activity prediction, accuracy rose from 0.52 to 0.79 with only 4 hours of processing; and in 2D semantic segmentation, precision advanced from 78.8% to 81.0% in a mere 30 hours.